Allergy:
An allergy is an over-reaction of the immune
system to a normally harmless substance called an
allergen.
Common allergens include pollen, animal dander,
down feathers, mites, chemicals, and a variety of
foods.
Some allergies primarily cause respiratory
symptoms like sneezing, stuffy and/or runny nose.
Others can cause diverse symptoms like a rash or
hives, lip or tounge swelling, wheezing, and
shorthness of breath or decreased blood pressure.
Allergies can be acute, chronic or seasonal.
Allergic rhinitis is a common type of allergy.
On first exposure, the inhaled allergen enters the
mucous membrane lining the nasal passages where it
is taken up by the antigen-presenting cell which
presents it to the T cells.
These T cells activate the B cells to release
substances called IgE antibodies against the
allergen.
These IgE antibodies sit on the surface of the
mast cells.
The mast cells have granules containing chemical
mediators like histamine and prostaglandins etc.
On exposure the allergen binds to the IgE
antibodies present on the mast cells, crosslinking
them.
This results in the release of histamine,
prostaglandins and other mediators into the
surrounding tissue.
These mediators cause dialation of the surrounding
blood vessels and increase their permeability.
This results in the nasal stuffiness, sneezing and
mucous discharge of allergic rhinitis. If more
severe, a generalized reaction with other, more
severe symptoms may occur.
Antihistamines are
the medications most commonly used to diminish
allergic symptoms. Antihistamines work by blocking
the action of histamines at its receptors and thus
decreasing the body's reaction to allergen.
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