PPI
Therapy
The
inner surface of the stomach is formed into
numerous gastric pits from which acid is secreted.
The
cells lining the gastric pits are:
·
Mucous neck cells which secrete mucous,
·
The
G cells which secrete gastin
·
The
parietal cells which secrete hydrochloric acid
The
proton pump present in parietal cells is
responsible for acid secretion
The
proton pump is located in the luminal side of the
parietal cell
Parts:
·
Proton pump
·
Proton
·
Potassium
·
ATP
The
proton pump actively transports proton into the
stomach lumen and potassium back to the parietal
cell with hydrolysis of ATP.
Proton
pump inhibitors are drugs which reduce acid
secretion of the stomach.
The drug
passes unchanged through the stomach and is
absorbed in the small intestine.
The drug
binds irreversibly to the proton pump and prevents
the active transport of protons. This dramatically
decreases the acid secretion of the stomach
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